Schedule
– Advanced Genetics
- PCB 5065 - Fall 2009
Section
2191, MTWR 5th Period, 2318 Fifield
Hall
|
Date |
Instructor |
Topic |
|
|
Mon |
Aug 24 |
All |
Course
introduction |
|
Tues |
Aug 25 |
The gene
in molecular terms |
|
|
Wed |
Aug 26 |
Hannah |
The gene
pre-Mendel to Mendel |
|
Thurs |
Aug 27 |
Hannah |
The gene
as a unit of function |
|
|
|
|
|
|
Mon |
Aug 31 |
Hannah |
The gene
as a unit of mutation |
|
Tues |
Sept 1 |
Hannah |
The rII
cistron of phage T4 |
|
Wed |
Sept 2 |
Hannah |
The gene
and the operon |
|
Thurs |
Sept 3 |
Hannah |
Allelic
interactions - cistrons and operons ; Genic interactions - epistasis |
|
|
|
|
|
|
Mon |
Sept 7 |
|
Labor
Day Holiday – No Class |
|
Tues |
Sept 8 |
Hannah |
Transposable
elements I - molecular and genetic properties |
|
Wed |
Sept 9 |
Hannah |
Transposable
elements II - tools of forward and reverse genetics |
|
Thurs |
Sept 10 |
Hannah |
Forward
and reverse genetics - further approaches |
|
|
|
|
|
|
Mon |
Sept
14 |
Chase
/ Hannah |
Discussion
paper on genes, mutations and transposons |
|
Tues |
Sept 15 |
Segregation,
assortment, chromosome mechanics, nondisjunction |
|
|
Tues |
Sept
15 |
6:15-8:10
PM |
Exam
1 – Genes, Mutations & Transposons |
|
Wed |
Sept 16 |
Gabriel |
Genes
& chromosomes |
|
Thurs |
Sept 17 |
Gabriel |
Linkage,
gene order, linearity, crossing-over, recombination |
|
|
|
|
|
|
Mon |
Sept 21 |
Gabriel |
Tetrad
analysis & sister-strand exchange |
|
Tues |
Sept 22 |
Gabriel |
Mechanisms
of crossing over - gene conversion & |
|
Wed |
Sept 23 |
Gabriel |
Mechanisms
of crossing over - Messelson-Radding gene
conversion |
|
Thurs |
Sept 24 |
Gabriel |
Mechanisms
of crossing over – double-strand-break repair model |
|
|
|
|
|
|
Mon |
Sept 28 |
Gabriel |
Mechanisms
of crossing over – synthesis dependent strand annealing and early
cross-over decision consensus models |
|
Tues |
Sept 29 |
Gabriel |
Mechanisms
of crossing over - Parasexuality and mitotic recombination
|
|
Wed |
Sept 30 |
Gabriel |
Site-specific
recombination systems |
|
Thurs |
Oct
1 |
Chase |
Discussion
paper on recombination |
|
|
|
|
|
|
Mon |
Oct 5 |
Chromosome
structure and organization |
|
|
Mon |
Oct
5 |
6:15-8:10
PM |
Exam
2 – Recombination |
|
Tues |
Oct 6 |
Moore |
Chromosome
function |
|
Wed |
Oct 7 |
|
Chromosome
variation |
|
Thurs |
Oct 8 |
Moore |
Genome
organization |
|
|
|
|
|
|
Mon |
Oct 12 |
|
Molecular
markers |
|
Tues |
Oct 13 |
Moore |
Molecular
markers |
|
Wed |
Oct 14 |
|
Linkage
mapping I |
|
Thurs |
Oct 15 |
|
Linkage
mapping II |
|
|
|
|
|
|
Mon |
Oct 19 |
Moore |
Physical
mapping |
|
Tues |
Oct 20 |
Moore |
Positional
cloning |
|
Wed |
Oct
21 |
Chase
/Moore |
Discussion
paper on chromosomes, genomes, markers & maps |
|
Thurs |
Oct 22 |
Non-Mendelian
inheritance - organelle inheritance I |
|
|
Thurs |
Oct
22 |
6:15-8:10
PM |
Exam
3 – Chromosomes, genomes, markers& maps |
|
|
|
|
|
|
Mon |
Oct 26 |
Chase |
Non-Mendelian
inheritance - organelle inheritance II |
|
Tues |
Oct 27 |
Chase |
Non-Mendelian
inheritance - maternal effects, cytoplasmic microorganisms, meiotic
drive |
|
Wed |
Oct 28 |
Chase |
Non-Mendelian
inheritance – epigenetics I |
|
Thurs |
Oct 29 |
No Class |
|
|
|
|
|
|
|
Mon |
Nov 2 |
Chase |
Non-Mendelian
inheritance – epigenetics II |
|
Tues |
Nov 3 |
McCarty |
Developmental
genetics - general concepts |
|
Wed |
Nov 4 |
McCarty |
Developmental
genetics – drosophila I |
|
Thurs |
Nov 5 |
McCarty |
Developmental
genetics – drosophila II |
|
|
|
|
|
|
Mon |
Nov 9 |
McCarty |
Developmental
genetics – plants I |
|
Tues |
Nov 10 |
McCarty |
Developmental
genetics – plants II |
|
Wed |
Nov 11 |
NO CLASS |
Veterans
Day Holiday |
|
Thurs |
Nov
12 |
McCarty |
Developmental
genetics - plants, cont. |
|
|
|
|
|
|
Mon |
Nov 16 |
Kirst |
Population
genetics - Hardy-Weinberg equilibrium |
|
Mon |
Nov
16 |
6:15-8:10
PM |
Exam
4 – Non-Mendelian and developmental genetics |
|
Tues |
Nov 17 |
Kirst |
Population
genetics – segregation, recombination & linkage disequilibrium |
|
Wed |
Nov 18 |
Kirst |
Forces
that change gene frequencies: mutation |
|
Thurs |
Nov 19 |
Kirst |
Forces
that change gene frequencies: migration |
|
|
|
|
|
|
Mon |
Nov 23 |
Kirst |
Forces
that change gene frequencies: random genetic drift |
|
Tues |
Nov 24 |
Kirst |
Population
genetic structure & effective population size |
|
Wed |
Nov 25 |
Kirst |
Population
genetic structure & effective population size |
|
Thurs |
Nov 26 |
NO CLASS |
Thanksgiving
Holiday |
|
|
|
|
|
|
Mon |
Nov 30 |
Kirst |
Natural
and artificial selection |
|
Tues |
Dec 1 |
Kirst |
Short
and long-term responses to selection |
|
Wed |
Dec 2 |
Kirst |
Heritability,
genetic correlation and gain from selection |
|
Thurs |
Dec 3 |
Kirst |
Molecular
dissection of quantitative variation – linkage analysis |
|
|
|
|
|
|
Mon |
Dec 7 |
Kirst |
Molecular
dissection of quantitative variation – association studies |
|
Mon |
Dec 7 |
Chase |
Take-home
Instructor evaluations given |
|
Tues
|
Dec
8 |
Kirst
/Chase |
Discussion
paper on population and quantitative genetics |
|
Wed |
Dec 9 |
Kirst |
Review /
question-answer session |
|
Wed |
Dec 9 |
|
Take-home
Instructor evaluations due |
|
Wed |
Dec
9 |
6:15-8:10
PM |
Exam
5– Population & quantitative genetics |