PCB5065 Advanced Genetics Fall 2009
Required discussion papers
Required discussion paper 1 :

Storkebaum E, Leitão-Gonçalves R, Godenschwege T, Nangle L, Mejia M, Bosmans I, Ooms T, Jacobs A, Van Dijck P, Yang XL, Schimmel P, Norga K, Timmerman V, Callaerts P, Jordanova A. (2009) Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.
Proc Natl Acad Sci USA 106(28):11782-7

Discussion questions

Required discussion paper 2 and commentaries:

Townsend JA, Wright DA, Winfrey RJ, Fu F, Maeder ML, Joung JK, Voytas DF (2009) High-frequency modification of plant genes using engineered zinc-finger nucleases.
Nature 459:442-5
Supplementary information

Porteus, MH (2009) Plant biotechnology: Zinc fingers on target.
Nature 459:337-8

High, KA (2005) The moving finger
Nature 435:577-79

Discussion questions

Required discussion paper 3:

Davis, BW, T Raudsepp, AJ Pearks  Wilkerson, R Agarwala, AA Schaffer, M Houck, BP Chowdhary, WJ Murphy (2009) A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae.
Genomics 93:299-304

Discussion questions

Required discussion paper 4  cancelled to allow for an additional class on developmental genetics!

Johannes, F, A Porcher, FK Teixeira, V Saliba-Colombani, M Simon, N Agier, A Bulski, J Albuisson, F Heredia, P Audigier, D Bouchez, C Dillmann, P Guerche, F Hosiptal, V Colot (2009) Asessing the impact of transgenerational epigenetic variation on complex traits.
PLOS Genetics 5 (6): e10000530

Richards, EJ (2009) Quantitative epigenetics: DNA sequence variation need not apply. Genes & Deve 23:1601-1605

Discussion questions
 
Required discussion paper 5 and commentaries:



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