Eudes A, Bozzo GG, Waller JC, Naponelli V, Lim E-K, Bowles DJ, Gregory JF 3rd, Hanson AD (2008)
Metabolism of the folate precursor p-aminobenzoate in plants: Glucose ester formation and vacuolar storage.
J Biol Chem, Apr  2008; [Epub ahead of print]

Naponelli V, Noiriel A, Ziemak MJ, Beverley SM, Lye L-F, Plume AM, Botella JR, Loizeau K, Ravanel S, Rébeillé F, de Crécy-Lagard V, Hanson AD (2008)
Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.
Plant Physiol 146: 1515-1527.

Bozzo GG, Basset GJ, Naponelli V, Noiriel A, Gregory JF 3rd, Hanson AD (2008)
Characterization of the folate salvage enzyme p-aminobenzoylglutamate hydrolase in plants.
Phytochem­istry 69: 29-37

de Crécy-Lagard V, Hanson AD (2007)
Finding novel metabolic genes through plant-prokaryote phylogenomics.
Trends Microbiol 15: 563-570

Naponelli V, Hanson AD, Gregory JF 3rd (2007)
Improved methods for the preparation of [3H]folate polyglutamates: biosynthesis with Lactobacillus casei and enzymatic synthesis with Escherichia coli folylpolyglutamate synthetase.
Anal Biochem 371: 127-134

Nerlich A, von Orlow M, Rontein D, Hanson AD, Dörmann P (2007)
Deficiency in phosphateidylserine decarboxylase activity in the psd1 psd2 psd3 triple mutant of Arabidopsis affects phos­phatidylethanolamine accumulation in mitochondria.
Plant Physiol 144: 904-914

Noiriel A, Naponelli V, Bozzo GG, Gregory JF 3rd, Hanson AD (2007)
Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductases.
Plant J 51: 378-389

de Crécy-Lagard V, El Yacoubi B, Díaz de la Garza R, Noiriel A, Hanson AD (2007)
Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations.
BMC Genomics 8: 245

Díaz de la Garza RI, Gregory JF 3rd, Hanson, AD (2007)
Folate biofortification of tomato fruit.
Proc Natl Acad Sci USA 104: 4218-4222

Noiriel A, Naponelli V, Gregory JF 3rd, Hanson AD (2007)
Pterin and folate salvage: plants and Escherichia coli lack capacity to reduce oxidized pterins.
 Plant Physiol 143: 1101-1109

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD (2007)
Functional characterization of a methionine γ-lyase in Arabidopsis and its implication in an alternative to the reverse trans­sulfuration pathway.
Plant Cell Physiol 48: 232-242

Vickers TJ, Orsomando G, de la Garza RD, Scott DA, Kang SO, Hanson AD, Beverley SM (2006)
Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.
J Biol Chem 281: 38150-38158

Tieman D, Taylor M, Schauer N, Fernie AR, Hanson AD, Klee HJ (2006)
Tomato aromatic amino acid decarboxylases participate in synthesis of the flavor volatiles 2-phenylethanol and 2-phenylacetaldehyde.
Proc Natl Acad Sci USA 103: 8287-8292

Orsomando G, Bozzo GG, de la Garza RD, Basset GJ, Quinlivan EP, Naponelli V, Rébeillé F, Ravanel S, Gregory JF 3rd, Hanson AD (2006)
Evidence for folate-salvage reactions in plants.
Plant J 46: 426-435

Sahr T, Ravanel S, Basset G, Nichols BP, Hanson AD, Rébeillé F (2006)
Folate synthesis in plants: purification, kinetic properties, and inhibition of aminodeoxychorismate synthase.
Biochem J 396: 157-162

Wang Q, Hauser V, Read M, Wang P, Hanson AD, Sims PF, Hyde J
Functional identification of orthologous genes encoding pterin recycling activity in Plasmodium falciparum and Toxoplasma gondii
Mol Biochem Parasitol. 2005 Nov 28 Mol Biochem Parasitol 146: 109-112

Quinlivan EP, Hanson AD, Gregory JF
The analysis of folate and its metabolic precursors in biological samples
Anal Biochem. 2006 Jan 15;348(2):163-84

Klaus SM, Kunji ER, Bozzo GG, Noiriel A, Diaz de la Garza R, Basset GJ, Ravanel S, Rebeille F, Gregory JF 3rd, Hanson AD
Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids
J Biol Chem. 2005 Nov 18;280(46):38457-63

Orsomando G, Diaz de la Garza R, Green BJ, Peng M, Rea PA, Ryan TJ, Gregory JF 3rd, Hanson AD
Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles
J Biol Chem. 2005 Aug 12;280(32):28877-84

Goyer A, Collakova E, Diaz de la Garza R, Quinlivan EP, Williamson J, Gregory JF 3rd, Shachar-Hill Y, Hanson AD
5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves
J Biol Chem. 2005 Jul 15;280(28):26137-42

Klaus SM, Wegkamp A, Sybesma W, Hugenholtz J, Gregory JF 3rd, Hanson AD
A nudix enzyme removes pyrophosphate from dihyroneopterin triphosphate in the folate synthesis pathway of bacteria and plants
J Biol Chem. 2005 Jul 15;280(28):26137-42

Basset, G.J., Ravanel, S., Quinlivan, E.P., White, R., Giovannoni, J.J., Rébeillé, F., Nichols, B.P., Shinozaki, K., Seki, M., Gregory, J.F. III and Hanson, A.D.
Folate synthesis in plants: The last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyase
Plant J. 2004 Nov;40(4):453-61

Díaz de la Garza R, Quinlivan EP, Klaus SM, Basset GJ, Gregory JF 3rd, Hanson AD
Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis
Proc Natl Acad Sci U S A 2004 Sep21; 101(38):13720-13725

Goyer A, Illarionova V, Roje S, Fischer M, Bacher A, Hanson AD
Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases
Plant Physiol. 2004 May;135(1):103-11

Goyer A, Johnson TL, Olsen LJ, Collakova E, Shachar-Hill Y, Rhodes D, Hanson AD
Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis
J Biol Chem. 2004 Apr 23;279(17):16947-53

Basset GJC, EP Quinlivan, S Ravanel, F Rébeillé, BP Nichols, K Shinozaki, M Seki, LC Ad­ams-Phillips, JJ Giovannoni, JF Gregory 3rd, AD Hanson
Folate synthesis in plants: The p-amino­benzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids
Proc. Natl. Acad. Sci. USA 2004 Feb 10;101(6):1496-501

Rontein D, Rhodes D, and Hanson AD
Evidence from engineering that decarboxylation of free serine is the major source of ethanolamine moieties in plants
Plant Cell Physiol. 2003 Nov;44(11):1185-91

Rontein D, Wu WI, Voelker DR, Hanson AD
Mitochondrial phosphatidylserine decarboxylase from higher plants. Functional complementation in yeast, localization in plants, and overexpression in Arabidopsis
Plant Physiol. 2003 Jul;132(3):1678-87

Kocsis MG, Ranocha P, Gage DA, Simon ES, Rhodes D, Peel GJ, Mellema S, Saito K, Awazuhara M, Li C, Meeley RB, Tarczynski MC, Wagner C, Hanson AD
Insertional inactivation of the methionine s-methyltransferase gene eliminates the s-methylmethionine cycle and increases the methylation ratio
Plant Physiol. 2003 Apr;131(4):1808-15

Quinlivan EP, Roje S, Basset G, Shachar-Hill Y, Gregory JF 3rd, Hanson AD
The folate precursor p-aminobenzoate is reversibly converted to its glucose ester in the plant cytosol
J Biol Chem. 2003 Jun 6;278(23):20731-7

Basset G, Quinlivan EP, Ziemak MJ, Díaz de la Garza R, Fischer M, Schiffmann S, Bacher A, Gregory JF 3rd, and Hanson AD
 Folate synthesis in plants: The first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I
 PNAS 2002 99: 12489-12494

Roje S, Janave MT, Ziemak MJ, Hanson AD.
Cloning and characterization of mitochondrial 5-formyltetrahydrofolate cycloligase from higher plants
J Biol Chem. 2002 Aug; 277(45):42748-42754

Hanson AD, Gregory JF 3rd.
Synthesis and turnover of folates in plants
Curr Opin Plant Biol. 2002 Jun;5(3):244-9

Rontein D, Basset G, Hanson AD
Metabolic engineering of osmoprotectant accumulation in plants
Metab Eng. 2002 Jan;4(1):49-56. Review

Roje S, Chan SY, Kaplan F, Raymond RK, Horne DW, Appling DR, Hanson AD
Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo
J Biol Chem. 2002 Feb 8;277(6):4056-61

McNeil SD, Nuccio ML, Ziemak MJ, Hanson AD
Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):10001-5

Rontein D, Nishida I, Tashiro G, Yoshioka K, Wu WI, Voelker DR, Basset G, Hanson AD
Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme
J Biol Chem. 2001 Sep 21;276(38):35523-9

Hanson AD, Roje S
ONE-CARBON METABOLISM IN HIGHER PLANTS
Annu Rev Plant Physiol Plant Mol Biol. 2001;52:119-137

Ranocha P, McNeil SD, Ziemak MJ, Li C, Tarczynski MC, Hanson AD
The S-methylmethionine cycle in angiosperms: ubiquity, antiquity and activity
Plant J. 2001 Mar;25(5):575-84

Nuccio ML, McNeil SD, Ziemak MJ, Hanson AD, Jain RK, Selvaraj G
Choline import into chloroplasts limits glycine betaine synthesis in tobacco: analysis of plants engineered with a chloroplastic or a cytosolic pathway
Metab Eng. 2000 Oct;2(4):300-11

 McNeil SD, Rhodes D, Russell BL, Nuccio ML, Shachar-Hill Y, Hanson AD
Metabolic modeling identifies key constraints on an engineered glycine betaine synthesis pathway in tobacco
Plant Physiol. 2000 Sep;124(1):153-62

Kocsis MG, Hanson AD
Biochemical evidence for two novel enzymes in the biosynthesis of 3-dimethylsulfoniopropionate in Spartina alterniflora
Plant Physiol. 2000 Jul;123(3):1153-61

McNeil SD, Nuccio ML, Rhodes D, Shachar-Hill Y, Hanson AD
Radiotracer and computer modeling evidence that phospho-base methylation is the main route of choline synthesis in tobacco
Plant Physiol. 2000 May;123(1):371-80

Nuccio ML, Ziemak MJ, Henry SA, Weretilnyk EA, Hanson AD
cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme
J Biol Chem. 2000 May 12;275(19):14095-101

Hanson AD, Gage DA, Shachar-Hill Y
Plant one-carbon metabolism and its engineering.
Trends Plant Sci. 2000 May;5(5):206-13. Review

Ranocha P, Bourgis F, Ziemak MJ, Rhodes D, Gage DA, Hanson AD
Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis
J Biol Chem. 2000 May 26;275(21):15962-8

Roje S, Wang H, McNeil SD, Raymond RK, Appling DR, Shachar-Hill Y, Bohnert HJ, Hanson AD
Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants.
J Biol Chem. 1999 Dec 17;274(51):36089-96

Bourgis F, Roje S, Nuccio ML, Fisher DB, Tarczynski MC, Li C, Herschbach C, Rennenberg H, Pimenta MJ, Shen TL, Gage DA, Hanson AD
S-methylmethionine plays a major role in phloem sulfur transport and is synthesized by a novel type of methyltransferase
Plant Cell. 1999 Aug;11(8):1485-98

McNeil SD, Nuccio ML, Hanson AD
Betaines and related osmoprotectants. Targets for metabolic engineering of stress resistance
Plant Physiol. 1999 Aug;120(4):945-50

 Nuccio ML, Rhodes D, McNeil SD, Hanson AD
Metabolic engineering of plants for osmotic stress resistance
Curr Opin Plant Biol. 1999 Apr;2(2):128-34. Review

 Nuccio ML, Russell BL, Nolte KD, Rathinasabapathi B, Gage DA, Hanson AD
The endogenous choline supply limits glycine betaine synthesis in transgenic tobacco expressing choline monooxygenase
Plant J. 1998 Nov;16(4):487-96

 Kocsis MG, Nolte KD, Rhodes D, Shen TL, Gage DA, Hanson AD
Dimethylsulfoniopropionate biosynthesis in Spartina alterniflora1. Evidence that S-methylmethionine and dimethylsulfoniopropylamine are intermediates
Plant Physiol. 1998 May;117(1):273-81

 Russell BL, Rathinasabapathi B, Hanson AD
Osmotic stress induces expression of choline monooxygenase in sugar beet and amaranth
Plant Physiol. 1998 Feb;116(2):859-65

Trossat C, Rathinasabapathi B, Weretilnyk EA, Shen TL, Huang ZH, Gage DA, Hanson AD
Salinity promotes accumulation of 3-dimethylsulfoniopropionate and its precursor S-methylmethionine in chloroplasts
Plant Physiol. 1998 Jan;116(1):165-71

 Gage DA, Rhodes D, Nolte KD, Hicks WA, Leustek T, Cooper AJ, Hanson AD
A new route for synthesis of dimethylsulphoniopropionate in marine algae
Nature. 1997 Jun 26;387(6636):891-4

 Rathinasabapathi B, Burnet M, Russell BL, Gage DA, Liao PC, Nye GJ, Scott P, Golbeck JH, Hanson AD
Choline monooxygenase, an unusual iron-sulfur enzyme catalyzing the first step of glycine betaine synthesis in plants: prosthetic group characterization and cDNA cloning
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3454-8

Vojtechova M, Hanson AD, Munoz-Clares RA
Betaine-aldehyde dehydrogenase from amaranth leaves efficiently catalyzes the NAD-dependent oxidation of dimethylsulfoniopropionaldehyde to dimethylsulfoniopropionate
Arch Biochem Biophys. 1997 Jan 1;337(1):81-8